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Miltefosine

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About Miltefosine
Miltefosine (INN, trade names Impavido and Miltex) is an antiprotozoal drug. Originally developed as an antineoplastic, it is now registered and used by Zentaris GmbH in India, Colombia and Germany for the treatment of visceral and cutaneous leishmaniasis, and is undergoing clinical trials for this use in several other countries, such as Brazil and Guatemala. It is currently the only effective oral treatment for leishmaniasis.

Recent animal studies suggest miltefosine may also be effective against Trypanosoma cruzi, the parasite responsible for Chagas' disease, and several pathogenic fungi, including Cryptococcus neoformans, Candida, Aspergillus and FUSArium.

Hexadecyltrimethylammonium bromide, a compound structurally similar to miltefosine, was recently found to exhibit potent in vitro activity against Plasmodium falciparum.

Source: Wikipedia




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