An early mention of goji berry occurs in the 7th century Tang Dynasty treatise Yaoxing Lun. It is also discussed in the 16th century Ming Dynasty Compendium of Materia Medica of Li Shizhen. Goji berry leaves may be used to make tea and Lycium root bark (called dìgǔpí in Chinese) for traditional Chinese medicine treatment of inflammation and some types of skin diseases. Glucopyranoside and phenolic amides isolated from wolfberry root bark exhibit inhibitory activity in vitro against human pathogenic bacteria and fungi. Goji Berry contains zeaxanthin, an important dietary carotenoid antioxidant. Published studies have also reported possible medicinal benefits of Lycium barbarum, especially due to its antioxidant properties, including potential benefits against cardiovascular and inflammatory diseases,vision-related diseases (such as age-related macular degeneration and glaucoma), having neuroprotective properties or as an anticancer and immunomodulatory agent.