When unwell, people for whom this remedy is best suited may moan with pain and feel that they are going out of their minds. They tend to feel anxious and restless, wishing that they could keep still. They may have a sensation as though their bones are broken. Eupatorium per. is usually given for influenza or malarial fever accompanied by pain in the limbs. Fever typically starts as a chill, then generates heat, sweating, and a strong thirst, accompanied by pains in the bones and great restlessness. Further symptoms that may be treated include vomiting of bile, and headaches that feel worse during the sweating phase. Native Americans used a boneset infusion for colds, fever, arthritis, and rheumatic pain. It became popular with European settlers due to its ability to stimulate the immune system against fever. Boneset was traditionally used for fevers and is said to be a principal Native American remedy for malaria. It became known to the European settlers and was used in New York in 1830 to treat malaria. It is also said to have been recommended in ancient times by Dioscorides for ulcers, dysentery, reptile bites, chronic fevers, and liver disease. The plant is used in herbal medicine for flu with aches and pains. Eupatorium per. is used mainly to treat flu and other feverish illnesses where characteristically there is tremendous bone pain and fever with scanty perspiration and restlessness because of the pain. The head, eyeballs, and chest are sore and there is a desire for ice-cold water and cold food. There may be a cough that exacerbates symptoms and can be relieved by going on all fours.