Podophyllotoxin, otherwise known as podofilox, is a non-alkaloid toxin in the lignan family present at concentrations of 0.3 to 1.0% by mass in the rhizome of American Mayapple (Podophyllum peltatum). Another common source of podophyllotoxin is the rhizomes of Podophyllum hexandrum Royle (Berberidaceae). It is synthetised biologically from two molecules of coniferyl alcohol by phenolic oxidative coupling and a series of oxidations, reductions and methylations The melting point of Podophyllotoxin is 183.3 - 184.0 °C. Podophyllotoxin is the pharmacological base for the important anti-cancer drug etoposide. It is also used as a gel or solution to treat genital warts.