Those who respond well to Colchicum are typically weak and restless. They may be depressed or irritable, and have poor concentration and memory, so that they appear dazed even though they may answer questions correctly. There is a marked absence of any apprehension and no discernible feat of death. The key symptoms linked with Colchicum focus on the muscle tissues and joint membranes, especially the membranes in the small joints. The joints may be painful, hot, and swollen, and the muscles extremely relaxed and even limp. Arthritic joint pain or gout may be so severe that it causes screaming if the joints are touched or jolted. There may be a twitching, tingling sensation all over the body. Colchicum is also considered a useful remedy for ulcerative colitis and for nausea with colicky pains and painful distension of the abdomen. Illness is typically accompanied by a feeling of icy coldness in the stomach. In addition to any other symptoms, the body may feel cold inside, with extreme oversensitivity to external stimuli such as bright lights, strong odors, physical contact, and even other people's behavior. During classical times, the herb was considered too toxic for use. Arabian physicians used it in the Middle Ages for joint pain and gout. The ancient Greeks found autumn crocus to be invaluable in the treatment of gout and rheumatism, and it was called "the soul of the joints." Colchicum has also been used for bronchitis, dropsy, fevers, venereal disease, neuroses, and convulsions. The key use of Colchicum is for gout where the pain is severe and touch or the slightest motion is unbearable. Characteristically, the big toe is the most affected and the pain causes extreme sensitivity. Colchicum is also used to treat digestive disorders such as heartburn, nausea, vomiting, and diarrhea, which are better for bending forward. Colchicum also helps heart disorders and muscle and joint complaints.