Common Uses:Off Label Uses:Side Effects:
Adverse reactions associated with Unithroid or levothyroxine therapy are primarily those of hyperthyroidism due to therapeutic overdosage. They include the following:

General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating;

Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia;

Musculoskeletal: tremors, muscle weakness;

Cardiac: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest;

Pulmonary: dyspnea;

Gl: diarrhea, vomiting, abdominal cramps;

Dermatologic: hair loss;

Reproductive: menstrual irregularities, infertility.

Pseudotumor cerebri has been reported in children receiving levothyroxine therapy. Seizures have been reported rarely with the institution of levothyroxine therapy. Inadequate levothyroxine dosage will produce or fail to ameliorate the signs and symptoms of hypothyroidism.

Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various Gl symptoms (abdominal pain, nausea, vomiting and diarrhea), fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine itself is not known to occur.

Cautions / Warnings:Drug Interactions:
Prior to starting on Unithroid, it is advisable to inform your physician regarding all prescription and nonprescription drugs you may use, especially of: warfarin, digoxin, estrogen products (including estrogen-containing birth control pills), diabetes medicines (e.g., insulin, glipizide, rosiglitazone), amiodarone, iodide (including radiographic contrast agents containing iodine), lithium, anti-thyroid agents (e.g., methimazole, propylthiouracil), androgens/anabolic steroids, glucocorticoids (e.g., dexamethasone, prednisone), high dose salicylates (e.g., aspirin), phenobarbital, rifamycins (e.g., rifampin), beta blockers (e.g., propranolol), antidepressants (e.g., amitriptyline, maprotiline, sertraline), cytokines (e.g., interferon-alpha, interleukin-2), growth hormones, ketamine, theophylline.

Certain medicines may decrease absorption of this drug into your bloodstream. Therefore, take Unithroid four hours apart from: calcium supplements, iron supplements, antacids, simethicone, orlistat, cholestyramine, colesevelam, colestipol, sucralfate, sodium polystyrene sulfonate.

Certain foods may decrease absorption of this medication when taken at the same time. Take Unithroid separately from: soybean flour (soybean infant formula), walnuts, dietary fiber.