Bromelain is a mixture of enzymes found naturally in the juice and stems of pineapples. Called a proteolytic enzyme, bromelain is believed to help with the digestion of protein. Some bromelain appears to be absorbed by the body intact, so it's also thought to have effects outside the digestive tract. In fact, bromelain is often marketed as a natural anti-inflammatory for conditions such as arthritis. It's one of the most popular supplements in Germany, where it is approved by the Commission E for the treatment of inflammation and swelling of the nose and sinuses due to surgery or injury. A topical form of bromelain is also being explored experimentally for burns. When used for as a digestive aid, bromelain is usually taken with meals. When used for inflammatory conditions, practitioners typically recommend taking bromelain between meals on an empty stomach to maximize absorption.