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Florinef
Fludrocortisone Acetate
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There is currently no information to display in this section. RateADrug provides information about drugs and supplements though a wiki format provided by researchers, health care providers and others. We encourage you to add to this description by clicking on the button below.
Common Uses:
Florinef Acetate is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
Off Label Uses:
Off label uses of Florinef include chronic fatigue syndrome and orthostatic hypotension.
Side Effects:
Most side effects are caused by Florinef's mineralocorticoid activity (retention of sodium and water) include hypertension, edema, cardiac enlargement, congestive heart failure, potassium loss, and hypokalemic alkalosis.
When Florinef or fludrocortisone is used in the small dosages recommended, the glucocorticoid side effects often seen with cortisone and its derivatives are not usually a problem; however the following untoward effects should be kept in mind, particularly when fludrocortisone is used over a prolonged period of time or in conjunction with cortisone or a similar glucocorticoid.
Musculoskeletal—muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humeral heads, pathologic fracture of long bones, and spontaneous fractures.
Gastrointestinal—peptic ulcer with possible perforation and hemorrhage, pancreatitis, abdominal distention, and ulcerative esophagitis.
Dermatologic—impaired wound healing, thin fragile skin, bruising, petechiae and ecchymoses, facial erythema, increased sweating, subcutaneous fat atrophy, purpura, striae, hyperpigmentation of the skin and nails, hirsutism, acneiform eruptions, and hives; reactions to skin tests may be suppressed.
Neurological—convulsions, increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment, vertigo, headache, and severe mental disturbances.
Endocrine—menstrual irregularities; development of the cushingoid state; suppression of growth in children; secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress (e.g., trauma, surgery, or illness); decreased carbohydrate tolerance; manifestations of latent diabetes mellitus; and increased requirements for insulin or oral hypoglycemic agents in diabetics.
Ophthalmic—posterior subcapsular cataracts, increased intraocular pressure, glaucoma, and exophthalmos.
Metabolic—hyperglycemia, glycosuria, and negative nitrogen balance due to protein catabolism.
Allergic Reactions—allergic skin rash, maculopapular rash, and urticaria.
Cautions / Warnings:
Before taking Florinef or fludrocortisone, it is advisable to inform your physician regarding any allergies one has to it or any other allergies.
Florinef should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: fungal infection in your blood (e.g., candidiasis, valley fever).
Before using Flornief, tell your doctor or pharmacist your medical history, especially of: bleeding problems, blood clots, brittle bones (osteoporosis), diabetes, eye problems (e.g., cataracts, glaucoma, infection of the eye), heart problems (e.g., congestive heart failure), high blood pressure, infections (e.g., herpes, tuberculosis), kidney disease, liver disease (e.g., cirrhosis), mental/mood disorders (e.g., anxiety, depression, psychosis), low blood minerals (e.g., calcium, potassium), stomach/intestinal problems (e.g., diverticulitis, peptic ulcer disease, ulcerative colitis), seizures, underactive thyroid (hypothyroidism).
Florinef or fludrocortisone makes your body hold on to salt (sodium) and get rid of other salts (e.g., calcium, potassium). Follow your doctor's advice on how much salt, potassium, and calcium should be in your diet.
Florinef may mask signs of infection or put you at greater risk of developing very serious infections. Report any injuries or signs of infection (e.g., persistent sore throat/fever/cough, pain while urinating, skin sores) that occur during treatment.
Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.
Avoid exposure to chickenpox or measles infection while taking this medication unless you have previously had these infections (e.g., in childhood). If you are exposed to either of these infections and you have not previously had them, seek immediate medical attention.
If you have been taking Florinef for a long time, your body may not produce enough natural steroids. You may need to start taking additional corticosteroids, especially if your body is stressed due to a major infection, surgery or injury. Deaths due to low steroid levels have sometimes occurred during such stresses.
Before having surgery, tell your doctor or dentist that you are using this medication or have taken it within the last 12 months.
If you have a history of ulcers or take large doses of aspirin or other arthritis medicine, limit alcoholic beverages while taking this medication to lower the risk of stomach/intestinal bleeding.
If you have diabetes, this drug may make it harder to control your blood sugar levels. Monitor your blood sugar levels regularly and inform your doctor of the results. Your diabetic medication or diet may need to be adjusted.
Caution is advised when using this drug in children because there is a slight risk that it may temporarily slow down a child's growth rate, but this will probably not affect final adult height. Though this effect is rare, monitor your child's height regularly.
The elderly may be more sensitive to the effects of this drug, especially water retention.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for an extended time may have low levels of corticosteroid hormone. Tell your doctor immediately if you notice symptoms such as persistent nausea/vomiting, severe diarrhea, or weakness in your newborn.
Florinef passes into breast milk and may have undesirable effects on a nursing infant. Therefore, it is important for nursing mothers to consult their physicians prior to starting on Florinef.
Drug Interactions:
The following drugs may interact with Florinef:
Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)—enhanced hypokalemia. Check serum potassium levels at frequent intervals; use potassium supplements if necessary.
Digitalis glycosides—enhanced possibility of arrhythmias or digitalis toxicity associated with hypokalemia. Monitor serum potassium levels; use potassium supplements if necessary.
Oral anticoagulants—decreased prothrombin time response. Monitor prothrombin levels and adjust anticoagulant dosage accordingly.
Antidiabetic drugs (oral agents and insulin)—diminished antidiabetic effect. Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary.
Aspirin—increased ulcerogenic effect; decreased pharmacologic effect of aspirin. Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy. Monitor salicylate levels or the therapeutic effect for which aspirin is given; adjust salicylate dosage accordingly if effect is altered.
Barbiturates, phenytoin, or rifampin—increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes. Observe the patient for possible diminished effect of steroid andincrease the steroid dosage accordingly.
Anabolic steroids (particularly C-17 alkylated androgens such as oxymetholone, methandrostenolone, norethandrolone, and similar compounds)—enhanced tendency toward edema. Use caution when giving these drugs together, especially in patients with hepatic or cardiac disease.
Vaccines—neurological complications and lack of antibody response.
Estrogen—increased levels of corticosteroid-binding globulin, thereby increasing the bound (inactive) fraction; this effect is at least balanced by decreased metabolism of corticosteroids. When estrogen therapy is initiated, a reduction in corticosteroid dosage may be required, and increased amounts may be required when estrogen is terminated.
Florinef may affect the nitrobluetetrazolium test for bacterial infection and produce false-negative results.
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Try adding more purple to your diet!
Purple foods such as concord grapes, blueberries, plums, pomegranates, acai berries, red wine, and even eggplants are very high in antioxidants. Purple foods have been shown to protect your heart and vision, promote mental focus, and increase longevity. Research has indicated that purple foods may even be used to prevent or cure cancer.
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Famous People with Diabetes
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SmallHalle Berry ALO-068274.jpg
Halle Berry
In 1989 Halle was diagnosed with type 1 diabetes.
SmallRandy Jackson CSH-042277.jpg
Randy Jackson
In 2001, weighing in at 355 lbs., Randy Jackson was diagnosed with type 2 diabetes.
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Wildly popular singer-songwriter, drummer and guitarist Nick Jonas, of Jonas Brothers fame, has figured out how to manage his type 1 diabetes.
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Edward James Olmos
The star of Miami Vice and Battlestar Gallactica is notable for NOT having diabetes—despite a strong genetic predisposition.
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Brittany Murphy
Thirty-two year old actress dies from cardiac arrest. She had type 2 diabetes and a thyroid condition, and it has been rumored that she also had a drug problem.
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Bret Michaels
Bret Michaels, frontman for glam metal band Poison,has had to learn how to manage his Type I diabetes during the insanity of touring.
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About Florinef
Florinef Acetate is the brand name of the generic drug fludrocortisone. The active ingredient of Florinef Acetate is fludrocortisone acetate. It is available in tablet form and is administered orally. The strength available in is 0.1 mg. Fludrocortisone, the active ingredient of Florinef Acetate belongs to a class of drugs called steroids, which prevent the release of substances in the body that cause inflammation. Florinef or fludrocortisone is used to treat conditions in which the body does not produce enough of its own steroids, such as Addison's disease, and salt-losing adrenogenital syndrome.
Source: Wikipedia
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