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6.7  Effectiveness
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RateADrug users have reported 6 Glipizide side effects and 2 Glipizide benefits.

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About Glipizide
Glipizide is the generic name and Glucotrol is the trade name or the brand name of the prescription drug which is used to treat type 2 diabetes which is non-insulin-dependent diabetes or adult-onset diabetes. Glipizide extended-release tablets or Glucotrol XL are also currently available. These tablets release the medication slowly, providing a more even level of medication in the blood. Brand-name glipizide or Glucotrol and Glucotrol XL is manufactured by Pfizer Inc., In its generic version, glipizide is manufactured by several pharmaceutical companies. Glipizide belongs to the sulfonylureas. Sulfonylureas function by aiding the pancreas generate more insulin. They also help the cells respond better to insulin. This helps decrease blood sugar and keep it under control. General considerations regarding glipizide include the following: Glipizide is available as tablets therefore it has to be taken orally. Glipizide is normally taken once or twice per day. To realize the maximum benefit of glipizide it is advisable to take glipizide before breakfast. In its' extended-release form glipizide is taken once daily along with breakfast. Glipizide tablets need to be taken orally without crushing, chewing or breaking them. In addition to the above, glipizide must be taken everyday at the same time each day to maintain an even level in your blood and glipizide should be taken regularly as prescribed by your physician.
About Glipizide
Glipizide is an oral medium-to-long acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation Sulfonylurea, which means that it undergoes enterohepatic circulation. The structure on the R2 group is a much larger cyclo or aromatic group compared to the 1st generation sulfonylureas. This leads to a once a day dosing that is much less than the first generation, about 100 fold.

Mechanism of action is produced by blocking potassium K+ channels in the Beta cells of the Islets of Langerhans. By partially blocking the K+ channels, you will increase the time the cell spends in the Calcium release stage of cell signaling leading to an increase in calcium. The increase in Calcium will initiate more Insulin release from each Beta cell.

Originally available in 1984, it is marketed by Pfizer under the brand name Glucotrol® in the USA, where Pfizer sells Glucotrol in doses of 5 and 10 milligrams and Glucotrol XL (an extended release form of glipizide) in doses of 2.5, 5, and 10 milligrams. Other companies sell generic forms of glipizide, most commonly extended release tablets of 5 and 10 milligrams.

Source: Wikipedia

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