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Rocaltrol
Calcitriol
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There is currently no information to display in this section. RateADrug provides information about drugs and supplements though a wiki format provided by researchers, health care providers and others. We encourage you to add to this description by clicking on the button below.
Common Uses:
Rocaltrol (calcitriol) is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body.
This is a form of vitamin D, a fat-soluble vitamin stored in the body. Vitamin D is necessary for normal bone development. This medication is used as a dietary supplement to help prevent and treat rickets (a vitamin D deficiency). It is also used to prevent and treat muscle cramps and certain types of calcium and phosphate disorders (such as with chronic dialysis), and to regulate parathyroid hormone.
Off Label Uses:
Off-label uses for Rocaltrol include increasing bone mass and preventing fractures in patients with osteoporosis and decreasing the severity of psoriatic lesions.
Side Effects:
The common side effects of Rocaltrol are:
Since Rocaltrol is believed to be the active hormone which exerts vitamin D activity in the body, adverse effects are, in general, similar to those encountered with excessive vitamin D intake, ie, hypercalcemia syndrome or calcium intoxication (depending on the severity and duration of hypercalcemia).
Early: weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, and anorexia, abdominal pain or stomach ache.
Late: polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated SGOT (AST) and SGPT (ALT), ectopic calcification, nephrocalcinosis, hypertension, cardiac arrhythmias, dystrophy, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections, and, rarely, overt psychosis.
Teratogenic Effects
Pregnancy Category C. Rocaltrol has been found to be teratogenic in rabbits when given at doses of 0.08 and 0.3 mcg/kg (approximately 2 and 6 times the maximum recommended dose based on mg/m2). All 15 fetuses in 3 litters at these doses showed external and skeletal abnormalities. However, none of the other 23 litters (156 fetuses) showed external and skeletal abnormalities compared with controls.
Teratogenicity studies in rats at doses up to 0.45 mcg/kg (approximately 5 times maximum recommended dose based on mg/m2) showed no evidence of teratogenic potential. There are no adequate and well-controlled studies in pregnant women. Rocaltrol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Cautions / Warnings:
Warnings and precautions while taking Rocaltrol.
Overdosage of any form of vitamin D is dangerous. Progressive hypercalcemia due to overdosage of vitamin D and its metabolites may be so severe as to require emergency attention. Chronic hypercalcemia can lead to generalized vascular calcification, nephrocalcinosis and other soft-tissue calcification. The serum calcium times phosphate product should not be allowed to exceed 70 mg2/dL2.
Radiographic evaluation of suspect anatomical regions may be useful in the early detection of this condition.
Rocaltrol is the most potent metabolite of vitamin D available. The administration of Rocaltrol to patients in excess of their daily requirements can cause hypercalcemia, hypercalciuria, and hyperphosphatemia. Therefore, pharmacologic doses of vitamin D and its derivatives should be withheld during Rocaltrol treatment to avoid possible additive effects and hypercalcemia. If treatment is switched from ergocalciferol (vitamin D2) to calcitriol, it may take several months for the ergocalciferol level in the blood to return to the baseline value.
Calcitriol increases inorganic phosphate levels in serum. While this is desirable in patients with hypophosphatemia, caution is called for in patients with renal failure because of the danger of ectopic calcification. A non-aluminum phosphate-binding compound and a low-phosphate diet should be used to control serum phosphorus levels in patients undergoing dialysis.
Excessive dosage of Rocaltrol induces hypercalcemia and in some instances hypercalciuria; therefore, early in treatment during dosage adjustment, serum calcium should be determined twice weekly. In dialysis patients, a fall in serum alkaline phosphatase levels usually antedates the appearance of hypercalcemia and may be an indication of impending hypercalcemia. An abrupt increase in calcium intake as a result of changes in diet (eg, increased consumption of dairy products) or uncontrolled intake of calcium preparations may trigger hypercalcemia.
Drug Interactions:
Some of the drug interactions that could result when used in conjuctions with other medications is as stated below:
Cholestyramine
Cholestyramine has been reported to reduce intestinal absorption of fat-soluble vitamins; as such it may impair intestinal absorption of Rocaltrol.
Phenytoin/Phenobarbital
The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of calcitriol, but may reduce endogenous plasma levels of 25(OH)D3 by accelerating metabolism. Since blood level of calcitriol will be reduced, higher doses of Rocaltrol may be necessary if these drugs are administered simultaneously.
Thiazides
Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. Some reports have shown that the concomitant administration of thiazides with Rocaltrol causes hypercalcemia. Therefore, precaution should be taken when coadministration is necessary.
Digitalis
Calcitriol dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias.
Ketoconazole
Ketoconazole may inhibit both synthetic and catabolic enzymes of calcitriol. Reductions in serum endogenous calcitriol concentrations have been observed following the administration of 300 mg/day to 1200 mg/day ketoconazole for a week to healthy men. However, in vivo drug interaction studies of ketoconazole with Rocaltrol have not been investigated.
Corticosteroids
A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption.
Phosphate-Binding Agents
Since Rocaltrol also has an effect on phosphate transport in the intestine, kidneys and bones, the dosage of phosphate-binding agents must be adjusted in accordance with the serum phosphate concentration.
Vitamin D
Since calcitriol is the most potent active metabolite of vitamin D3, pharmacological doses of vitamin D and its derivatives should be withheld during treatment with Rocaltrol to avoid possible additive effects and hypercalcemia.
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Cirrhosis of the liver
Cold
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Constipation
Crohn's Disease
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Diabetes Type 1
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Diarrhea & Bowel Disorder
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Enlarged Prostate (BHP)
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Fever
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Flu
Fungal Infection
Gastrius
Gastrointestinal & Stomach Problem
Gastroparesis
Gingivitis
Glaucoma
Gliomas
Gout
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Harth pain
Hashimoto's Hypothyroidism
Hay Fever
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Hyperparathyroid hypercalcemia
Hyperthyroidism
Hypothyroidism
Immune System Support
Incontinence
Insomnia & Sleeping Disorder
Insonmia
Irritable Bowel Syndrome
Joint Support
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Labor & Childbirth
Leprosy
Lichan planus
Lichen sclerosus
Liver Disorder
Lou Gehrig's Disease
Low Blood Pressure (Hypotension)
Lung Cancer
Lung Disease
Lupus
Malaria
Male Enhancement
Mcardle's Disease
Medicine / Fluid Absorption
Meniere's disease
Meniere's Disease & Vertigo
Meningitis
Menopause
Mental Health
Microscopic colitis
Migraine
Mild splenomegaly
Motion Sickness
Mouth & Gum Disorder
MRSA
Multiple Sclerosis (MS)
Muscle Building
Muscle Sprains & Strains
Muscle Strength
Muscular Dystrophy
Myasthenia Gravis
Narcolepsy
Nausea
Nerve Damage
Neuralgia
Nutrient Deficiency
Obsessive Compulsive Disorder
Osteoarthritis
Osteoporosis & Bone Disease
Ovarian Cysts
Pain Relief
Pancreatic Cancer
Parasites
Parkinson
Parkinsons
Parkinson's Disease
Perioral parasthesia
Pneumonia
Poison & Overdose
Premenstrual Syndrome (PMS) & Menstruation
Prostate Cancer
Protrusion of the disc
Psoriasis
Raynaud's Disease
Reproductive Health & Fertility
Respiratory Tract Infection
Rheumatoid Arthritis
Rickets
Rosacea
Sarcoidosis
Schizophrenia & Psychotic Disorders
Scleroderma
Severe headache
Sexual Dysfunction
Sexually Transmitted Illness (STI)
Shojrens syndrome
Sinusitis (Sinus Infection)
Sjogren's Syndrome / Dry Mouth
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Purple foods such as concord grapes, blueberries, plums, pomegranates, acai berries, red wine, and even eggplants are very high in antioxidants. Purple foods have been shown to protect your heart and vision, promote mental focus, and increase longevity. Research has indicated that purple foods may even be used to prevent or cure cancer.
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About Rocaltrol
Rocaltrol is the brand name and calcitriol is the generic name. Rocaltrol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. Rocaltrol is available as capsules containing 0.25 mcg or 0.5 mcg calcitriol and as an oral solution containing 1 mcg/mL of calcitriol. All dosage forms contain butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) as antioxidants. In predialysis patients Rocaltrol is used in the management of secondary hyperparathyroidism and resultant metabolic bone disease in patients with moderate to severe chronic renal failure not yet on dialysis. In dialysis patients, Rocaltrol is indicated in the management of hypocalcemia and the resultant metabolic bone disease in patients undergoing chronic renal dialysis. In these patients, Rocaltrol administration increases calcium absorption, reduces serum alkaline phosphatase levels, and may decrease elevated parathyroid hormone levels and the histological manifestations of osteitis fibrosa cystica and defective mineralization. In hypoparathyroidism patients, Rocaltrol is also indicated in the management of hypocalcemia and its clinical manifestations in patients with postsurgical hypoparathyroidism, idiopathic hypoparathyroidism, and pseudohypoparathyroidism.
About Calcitriol
Rocaltrol (calcitriol) is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. All dosage forms contain butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) as antioxidants. The capsules contain a fractionated triglyceride of coconut oil, and the oral solution contains a fractionated triglyceride of palm seed oil. Gelatin capsule shells contain glycerin, parabens (methyl and propyl) and sorbitol. The two known sites of action of calcitriol are intestine and bone.
Source: Wikipedia
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