Claravis is used for treating severe acne in patients who do not respond to other medicines. It may also be used for other conditions as determined by your doctor.

Claravis is a retinoid. It works by reducing skin oil production, changing the characteristics of the skin oil, and preventing abnormal hardening of the skin.

Off label uses of Claravis include prevention of recurrence of oral cancer, leukoplakia, and oral lichen planus.

Cautions and warnings for Claravis include the following:

Women who are pregnant must not use Claravis. Women must also avoid becoming pregnant while taking this medication. Serious birth defects, miscarriages, and premature births have occurred when this drug has been used during pregnancy.

For female patients, two effective forms of birth control must be used for one month before starting Claravis, during use, and for one month after stopping this drug. You must also have monthly pregnancy-avoidance counseling from your doctor. Do not use "minipills" for birth control since they may not work as well with isotretinoin. If you are late in having your period, or if you have sexual intercourse at any time without using two effective forms of birth control, stop taking this medication and contact your doctor immediately.

After December 31, 2005, only patients enrolled in the iPLEDGE program may obtain and use isotretinoin. You will need to register with iPLEDGE and view a video at your doctor's office before receiving your prescription. Only physicians enrolled in iPLEDGE may prescribe isotretinoin, and only pharmacies enrolled in the program may dispense it. Consult your doctor or pharmacist for more details about the iPLEDGE program and for more information about the risks and benefits of using this medication.

For female patients who are able to become pregnant, you will need to contact iPLEDGE every month, either through the internet or by telephone, and answer required questions every time you fill your prescription and 1 month after your last dose.

These requirements apply in the United States. If you live in Canada or any other country, consult your doctor and pharmacist for your specific regulations.